Title:
METHOD FOR PREDICTING PRESENCE OF NON-SIMULTANEOUS METASTASIS OF COLON CANCER, AND KIT USED FOR THE SAME
Document Type and Number:
Japanese Patent JP2019013162
Kind Code:
A
Abstract:
To provide a method for predicting the presence of non-simultaneous metastasis in a colon cancer patient from a gene expression level in a tumor tissue acquired from the colon cancer patient.SOLUTION: A method for predicting the presence of non-simultaneous metastasis of a patient having stage 2 colon cancer has: a process of measuring an expression level of at least one gene selected from GNL3L, SLC35A2, UBE2I, IL2RB, and TYMP in a colon cancer tissue acquired from the patient; a process of calculating a score for predicting the presence of non-simultaneous metastasis from the measured expression level, which shows that non-simultaneous metastasis does not occur in the patient in the case where the calculated score is smaller than a reference value.SELECTED DRAWING: None
Inventors:
TAKEMASA ICHIRO
MATOBA AKIRA
MATOBA AKIRA
Application Number:
JP2017131258A
Publication Date:
January 31, 2019
Filing Date:
July 04, 2017
Export Citation:
Assignee:
DNA CHIP RESEARCH INC
UNIV SAPPORO MEDICAL
UNIV SAPPORO MEDICAL
International Classes:
C12Q1/68; C12Q1/04
Domestic Patent References:
| JP2012513752A | 2012-06-21 | |||
| JP2014158500A | 2014-09-04 |
Other References:
OKAMOTO, N., ET AL.: ""Maintenance of tumor initiating cells of defined genetic composition by nucleostemin."", PROC. NATL. ACAD. SCI. USA, vol. 108, no. 51, JPN6021010537, 2011, pages 20388 - 20393, ISSN: 0004587362
MOCSHOS, S. J., ET AL.: ""Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 cojugating enzyme,", HUMAN PATHOLOGY, vol. 41, JPN6021010539, 2010, pages 1286 - 1298, ISSN: 0004587363
NITCHE, ET AL.: ""Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer."", ANNALS OF SURGERY, vol. 256, no. 5, JPN6021010541, 2012, pages 763 - 771, ISSN: 0004694934
MOCSHOS, S. J., ET AL.: ""Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 cojugating enzyme,", HUMAN PATHOLOGY, vol. 41, JPN6021010539, 2010, pages 1286 - 1298, ISSN: 0004587363
NITCHE, ET AL.: ""Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer."", ANNALS OF SURGERY, vol. 256, no. 5, JPN6021010541, 2012, pages 763 - 771, ISSN: 0004694934
Attorney, Agent or Firm:
Taro Yaguchi