Title:
ANTI-LIPOARABINOMANNAN ANTIBODIES AND IMMUNOASSAY OF MYCOBACTERIOSIS USING ANTIBODIES
Document Type and Number:
Japanese Patent JP2019014717
Kind Code:
A
Abstract:
To provide monoclonal antibodies that specifically bind to lipoarabinomannan (LAM) of mycobacteria, in particular, of Mycobacterium tuberculosis.SOLUTION: Disclosed herein is an antibody capable of specifically detecting mycobacterial LAM discriminating it from other bacterial LAM or membrane antigens having similar structures with a sensitivity equal to the gene amplification method, which antibody is obtainable with devised animals for immunization, immunogen, monoclonal antibody preparation techniques and selection methods. Also disclosed are a method and a kit for detecting a mycobacterium using the antibody. The monoclonal antibody of the invention comprises a heavy chain variable region comprising heavy chain CDR1-CDR3 of specific sequences and a light chain variable region comprising light chain CDR1-CDR3 of specific sequences where the variable regions are linked through a linker.SELECTED DRAWING: None
Inventors:
KATSURAGI TOSHINORI
TOGASHI MASATAKA
ODA TETSUYA
ITO RYUTA
KAWAGUCHI TOMOE
SAIJO YOKO
KOGA DAISUKE
MATSUMOTO MAKOTO
FUJIWARA MAMORU
ONO KENJI
TOGASHI MASATAKA
ODA TETSUYA
ITO RYUTA
KAWAGUCHI TOMOE
SAIJO YOKO
KOGA DAISUKE
MATSUMOTO MAKOTO
FUJIWARA MAMORU
ONO KENJI
Application Number:
JP2018152839A
Publication Date:
January 31, 2019
Filing Date:
August 15, 2018
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD
International Classes:
C07K16/12; C12M1/34; G01N33/53; G01N33/569
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office