Title:
PRODUCTION METHOD OF COLLAPSE TABLET IN ORAL CAVITY
Document Type and Number:
Japanese Patent JP2019031461
Kind Code:
A
Abstract:
To provide a production method of a collapse tablet in an oral cavity having proper dissolubility which is a basic characteristic of the collapse tablet in an oral cavity and in which unpleasant taste caused by an included medicine is reduced efficiently.SOLUTION: The production method of the collapse tablet in an oral cavity comprises: a step for applying a layering solution including a medicine having an unpleasant taste and alkalization agent to core particles for acquiring plural layering particles; a step for applying a coating solution including a coating agent to the plural layering particles for acquiring plural masking particles; and a step for compressing the plural masking particles. A solvent forming the coating solution is alcohol, or mixture of alcohol and water, the alcohol being at least one kind selected from ethanol and methanol, and the solvent includes 30% (w/w) or more of alcohol.SELECTED DRAWING: None
Inventors:
KOBAYASHI YUTA
DOKE SHUNSUKE
JO TAKAAKI
DOKE SHUNSUKE
JO TAKAAKI
Application Number:
JP2017153490A
Publication Date:
February 28, 2019
Filing Date:
August 08, 2017
Export Citation:
Assignee:
NIPRO CORP
International Classes:
A61K9/20; A61K31/192; A61K31/196; A61K31/40; A61K31/404; A61K31/4422; A61K31/4439; A61K31/445; A61K31/496; A61K31/519; A61K31/5383; A61K47/02; A61K47/12; A61K47/32; A61K47/38; A61P13/00; A61P15/16; A61P43/00
Attorney, Agent or Firm:
Nakamichi Yoshihiro