Title:
STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES
Document Type and Number:
Japanese Patent JP2019052162
Kind Code:
A
Abstract:
To provide stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives.SOLUTION: An aqueous pharmaceutical formulation comprises: (a). at least one analogue and/or derivative of insulin; (b). Zn(II); (c). sodium chloride; and (d). optionally protamine. The pharmaceutical formulation has a pH value in the range from 6.0 and 9.0 and is free of any additional buffering agent.SELECTED DRAWING: None
Inventors:
OLIVER BLEY
PETRA LOOS
BERND BIDLINGMAIER
WALTER KAMM
HARALD BERCHTOLD
PETRA LOOS
BERND BIDLINGMAIER
WALTER KAMM
HARALD BERCHTOLD
Application Number:
JP2018221814A
Publication Date:
April 04, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
SANOFI SA
International Classes:
A61K38/28; A61K9/08; A61K9/10; A61K38/18; A61K45/00; A61K47/02; A61K47/10; A61K47/26; A61K47/42; A61P3/10; A61P43/00
Domestic Patent References:
| JPS63107941A | 1988-05-12 | |||
| JP2011503033A | 2011-01-27 | |||
| JP2012522788A | 2012-09-27 | |||
| JP2012530768A | 2012-12-06 |
Foreign References:
| WO2012174478A2 | 2012-12-20 | |||
| WO2012080320A1 | 2012-06-21 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi