Title:
N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B
Document Type and Number:
Japanese Patent JP2019077713
Kind Code:
A
Abstract:
To provide pharmaceutical compositions useful in treating a neurological disease, an abnormal brain function, and/or an emotional disorder such as bipolar disorder, obsessive-compulsive disorder, post-traumatic stress syndrome, or anxiety, by modulating NR2B receptors.SOLUTION: For example, the compositions comprise compounds having an N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole structure represented by the formula in the figure.SELECTED DRAWING: None
Inventors:
DAVID R ANDERSON
ROBERT A VOLKMANN
FRANK S MENNITI
ROBERT A VOLKMANN
FRANK S MENNITI
Application Number:
JP2019008873A
Publication Date:
May 23, 2019
Filing Date:
January 23, 2019
Export Citation:
Assignee:
CADENT THERAPEUTICS INC
International Classes:
C07D209/52; A61K31/403; A61K31/4155; A61K31/4439; A61K31/444; A61K31/4725; A61K31/497; A61K31/506; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12
Domestic Patent References:
| JP6473227B2 | 2019-02-20 | |||
| JP2008536927A | 2008-09-11 | |||
| JP2003513040A | 2003-04-08 |
Foreign References:
| US5726172A | 1998-03-10 | |||
| CN102432598A | 2012-05-02 | |||
| WO2015048507A1 | 2015-04-02 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Noriki Mitsuhashi
Yasuhito Suzuki
Norio Omori
Noriki Mitsuhashi
Yasuhito Suzuki