Title:
SCR-DELETED VACCINIA VIRUS
Document Type and Number:
Japanese Patent JP2019097564
Kind Code:
A
Abstract:
To provide a gene-deleted vaccinia virus useful for the prevention or treatment of cancer.SOLUTION: The present invention provides a recombinant vaccinia virus having a gene encoding B5R with deleted functions of vaccinia virus growth factor VGF and O1L and deleted SCR (short consensus repeat) domain.SELECTED DRAWING: None
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Inventors:
NAKAMURA TAKASHI
KUROSAKI SO
NAKATAKE HIROMU
KUROSAKI SO
NAKATAKE HIROMU
Application Number:
JP2018223349A
Publication Date:
June 24, 2019
Filing Date:
November 29, 2018
Export Citation:
Assignee:
ASTELLAS PHARMA INC
UNIV TOTTORI
UNIV TOTTORI
International Classes:
C12N7/04; A61K35/768; A61P35/00
Domestic Patent References:
| JP2006506974A | 2006-03-02 | |||
| JP6794442B2 | 2020-12-02 |
Foreign References:
| WO2015076422A1 | 2015-05-28 |
Other References:
ELIZABETH HERRERA ET AL.: "Functional Analysis of Vaccinia Virus B5R Protein: Essential Role in Virus Envelopment Is Independen", JOURNAL OF VIROLOGY, vol. 72, no. 1, JPN7022004763, 1998, pages 294 - 302, ISSN: 0004892303
ELIZABETH MATHEW ET AL.: "The Extracellular Domain of Vaccinia Virus Protein B5R Affects Plaque Phenotype, Extracellular Envel", JOURNAL OF VIROLOGY, vol. 72, no. 3, JPN7022004762, 1998, pages 2429 - 2438, ISSN: 0004892304
MOTOMU NAKATAKE ET AL.: "Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving", MOLECULAR THERAPY ONCOLYTICS, vol. 14, JPN6023011293, September 2019 (2019-09-01), pages 159 - 171, XP055656662, ISSN: 0005021195, DOI: 10.1016/j.omto.2019.05.003
ELIZABETH MATHEW ET AL.: "The Extracellular Domain of Vaccinia Virus Protein B5R Affects Plaque Phenotype, Extracellular Envel", JOURNAL OF VIROLOGY, vol. 72, no. 3, JPN7022004762, 1998, pages 2429 - 2438, ISSN: 0004892304
MOTOMU NAKATAKE ET AL.: "Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving", MOLECULAR THERAPY ONCOLYTICS, vol. 14, JPN6023011293, September 2019 (2019-09-01), pages 159 - 171, XP055656662, ISSN: 0005021195, DOI: 10.1016/j.omto.2019.05.003
Attorney, Agent or Firm:
Seiji Ohno
Yuko Matsuniya
Umeda Shinsuke
Hiroshi Morita
Yuko Matsuniya
Umeda Shinsuke
Hiroshi Morita