Title:
MODIFIED POLYNUCLEOTIDES FOR PRODUCTION OF PROTEINS
Document Type and Number:
Japanese Patent JP2019107022
Kind Code:
A
Abstract:
To provide nucleic acid based compounds or polynucleotides having features which are useful for optimizing formulation and delivery of nucleic acid based therapeutics.SOLUTION: An isolated polynucleotide comprises: (a) a first region of linked nucleosides, the first region encoding a polypeptide of interest, the polypeptide of interest having prescribed sequences; (b) a first flanking region located at a 5' terminus of the first region, the first flanking region comprising (i) a sequence of linked nucleosides selected from a native 5' UTR and (ii) at least one 5' terminal cap; and (c) a second flanking region located at a 3' terminus of the first region, the second flanking region comprising (i') a sequence of linked nucleosides selected from a native 3' UTR and (ii') a 3' tailing sequence of linked nucleosides.SELECTED DRAWING: Figure 1
Inventors:
STEPHANE BANCEL
TIRTHA CHAKRABORTY
ANTONIN DE FOUGEROLLES
SAYDA M ELBASHIR
MATTHIAS JOHN
ATANU ROY
SUSAN WHORISKEY
KRISTY M WOOD
PAUL HATALA
JASON P SCHRUM
KENECHI EJEBE
JEFF LYNN ELLSWORTH
JUSTIN GUILD
TIRTHA CHAKRABORTY
ANTONIN DE FOUGEROLLES
SAYDA M ELBASHIR
MATTHIAS JOHN
ATANU ROY
SUSAN WHORISKEY
KRISTY M WOOD
PAUL HATALA
JASON P SCHRUM
KENECHI EJEBE
JEFF LYNN ELLSWORTH
JUSTIN GUILD
Application Number:
JP2019039425A
Publication Date:
July 04, 2019
Filing Date:
March 05, 2019
Export Citation:
Assignee:
MODERNATX INC
International Classes:
C12N15/12
Foreign References:
| WO1999051637A1 | 1999-10-14 |
Other References:
GENOME BIOL., 2002, VOL. 3, NO. 3, PP. 1-10, JPN6015047779, ISSN: 0004320083
J. BIOL. CHEM., 1998, VOL.273, NO. 15, PP. 8910-8915, JPN6015047781, ISSN: 0004320084
J. BIOL. CHEM., 1998, VOL.273, NO. 15, PP. 8910-8915, JPN6015047781, ISSN: 0004320084
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura