Title:
METHOD FOR STABILIZING DIBUTYLHYDROXYTOLUENE
Document Type and Number:
Japanese Patent JP2019135245
Kind Code:
A
Abstract:
To provide a technique for increasing the thermal stability of dibutylhydroxytoluene and suppressing a decrease in the content thereof over time in a liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof.SOLUTION: By mixing, into the liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof, at least one selected from the group consisting of chondroitin sulfate ester, aspartic acid, alginic acid, an alginic acid derivative, pharmaceutically acceptable salts of these, cyanocobalamin, panthenol, tocopherol, and a tocopherol derivative, and by employing a resin including polybutylene terephthalate as a resin that constitutes an inner wall surface (such as the wall surface of an interior space in a spout portion and/or a lid wall surface facing a spout opening in the spout portion) of an accommodating container, the thermal stability of the dibutylhydroxytoluene in the liquid drug can be increased, adsorption of the dibutylhydroxytoluene to the container can be suppressed, and a decrease in the dibutylhydroxytoluene content over time can be suppressed.SELECTED DRAWING: None
Inventors:
NEMOTO FUKIKO
MATSUHISA KEIICHI
MATSUHISA KEIICHI
Application Number:
JP2019071484A
Publication Date:
August 15, 2019
Filing Date:
April 03, 2019
Export Citation:
Assignee:
SENJU PHARMA CO
International Classes:
A61K31/436; A61J1/05; A61K9/08; A61K31/185; A61K47/02; A61K47/10; A61K47/18; A61K47/20; A61K47/22; A61K47/36; A61P27/02; A61P29/00
Domestic Patent References:
| JP6509812B2 | 2019-05-08 | |||
| JP2010159249A | 2010-07-22 | |||
| JP2006249076A | 2006-09-21 | |||
| JP2011098960A | 2011-05-19 | |||
| JP2006232823A | 2006-09-07 | |||
| JP2005336153A | 2005-12-08 |
Foreign References:
| WO2013099861A1 | 2013-07-04 |
Attorney, Agent or Firm:
Junya Tanaka
Mizuya Kamiya
Kyoko Sakoda
Mizuya Kamiya
Kyoko Sakoda