Title:
USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (Btk)
Document Type and Number:
Japanese Patent JP2019151651
Kind Code:
A
Abstract:
To provide methods for treating a hematologic malignancy, such as a B-cell malignancy. a chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma or Waldenstrom's macroglobulinemia, in an individual.SOLUTION: In a method, a combination of a. ibrutinib or a pharmaceutically acceptable salt thereof at a dosage of 420-560 mg/day and b. an anti-CD20 antibody (specifically, rituximab or obinutuzumab, or a pharmaceutically acceptable salt thereof) is used in separate dosage forms.SELECTED DRAWING: None
Inventors:
JOSEPH J BUGGY
ELIAS LAURENCE
GWEN FYFE
ERIC HEDRICK
DAVID J LOURY
TARAK D MODY
ELIAS LAURENCE
GWEN FYFE
ERIC HEDRICK
DAVID J LOURY
TARAK D MODY
Application Number:
JP2019087022A
Publication Date:
September 12, 2019
Filing Date:
April 29, 2019
Export Citation:
Assignee:
PHARMACYLICS LLC
International Classes:
A61K31/519; A61K39/395; A61P7/00; A61P35/00; A61P35/02; A61P43/00
Foreign References:
| US20110184001A1 | 2011-07-28 |
Other References:
ＡＮＮ．ＯＮＣＯＬ．, vol. 22, JPN6018024211, June 2011 (2011-06-01), JP, pages 135, ISSN: 0004294806
血液フロンティア, vol. Ｖｏｌ．２０ Ｓ−１, JPN6018024212, 2010, JP, pages 113 - 118, ISSN: 0004294807
血液内科, vol. 62, no. 1, JPN6018024213, January 2011 (2011-01-01), JP, pages 43 - 50, ISSN: 0004294808
医学のあゆみ, vol. 235, no. 5, JPN6018024214, 2010, JP, pages 570 - 576, ISSN: 0004294809
血液フロンティア, vol. Ｖｏｌ．２０ Ｓ−１, JPN6018024212, 2010, JP, pages 113 - 118, ISSN: 0004294807
血液内科, vol. 62, no. 1, JPN6018024213, January 2011 (2011-01-01), JP, pages 43 - 50, ISSN: 0004294808
医学のあゆみ, vol. 235, no. 5, JPN6018024214, 2010, JP, pages 570 - 576, ISSN: 0004294809
Attorney, Agent or Firm:
Kazuhiro Kiyohara