Title:
炭酸無水酵素ＩＸ阻害剤抱合体およびその使用
Document Type and Number:
Japanese Patent JP2019515880
Kind Code:
A
Abstract:
本開示は、炭酸無水酵素ＩＸ阻害剤の組成物および方法に関する。本開示はまた、治療剤およびイメージング剤としての炭酸無水酵素ＩＸ阻害剤の標的抱合体に関する。本開示はまた、画像化方法および癌治療における炭酸無水酵素ＩＸ阻害剤の標的抱合体の使用に関する。
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Inventors:
Christopher Pee Remon
Aeon Cho Earl Vlahoff
Jonathan M. Shillingford
Paul Jay Kleindle
Aeon Cho Earl Vlahoff
Jonathan M. Shillingford
Paul Jay Kleindle
Application Number:
JP2018549266A
Publication Date:
June 13, 2019
Filing Date:
March 16, 2017
Export Citation:
Assignee:
ENDOCYTE, INC.
International Classes:
C07C311/51; A61K31/198; A61K31/27; A61K31/352; A61K31/77; A61K38/05; A61P35/00; A61P43/00; C07K5/10; C12Q1/02
Domestic Patent References:
| JP2014520076A | 2014-08-21 |
Foreign References:
| WO2014134543A1 | 2014-09-04 | |||
| WO2008101231A2 | 2008-08-21 |
Other References:
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RAMI, MAROUAN ET AL.: "Carbonic anhydrase inhibitors: Copper(II) complexes ofpolyamino-polycarboxylamido aromatic/heterocyc", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18(2),, JPN6021006779, 2008, pages 836 - 841, ISSN: 0004607946
WICHERT, MORENO ET AL.: "Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity matur", NATURE CHEMISTRY, vol. 7(3),, JPN6021006780, 2015, pages 241 - 249, ISSN: 0004607947
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RAMI, MAROUAN ET AL.: "Carbonic anhydrase inhibitors: Copper(II) complexes ofpolyamino-polycarboxylamido aromatic/heterocyc", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18(2),, JPN6021006779, 2008, pages 836 - 841, ISSN: 0004607946
WICHERT, MORENO ET AL.: "Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity matur", NATURE CHEMISTRY, vol. 7(3),, JPN6021006780, 2015, pages 241 - 249, ISSN: 0004607947
CECCHI, ALESSANDRO ET AL.: "Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carb", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48(15),, JPN6021006781, 2005, pages 4834 - 4841, ISSN: 0004454106
AHLSKOG, JULIA K. J. ET AL.: "In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(16),, JPN6021006782, 2009, pages 4851 - 4856, ISSN: 0004454107
CECCHI, ALESSANDRO ET AL.: "Carbonic anhydrase inhibitors: synthesis and inhibition ofcytosolic/tumor-associated carbonic anhydr", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14(23),, JPN6021006784, 2004, pages 5775 - 5780, ISSN: 0004454108
Attorney, Agent or Firm:
Norihito Yamao
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro