Title:
ＤＮＡメチル化の編集方法
Document Type and Number:
Japanese Patent JP2019528068
Kind Code:
A
Abstract:
本発明は、メチル化活性または脱メチル化活性を有するエフェクタードメインに融合された触媒不活性な部位特異的ヌクレアーゼ、及び１つ以上のガイド配列と細胞を接触させることによって、ＤＮＡメチル化を修飾する方法に関する。
Inventors:
Janish, rudolph
Riu, X. Shawn
Woo, Hao
Riu, X. Shawn
Woo, Hao
Application Number:
JP2019510362A
Publication Date:
October 10, 2019
Filing Date:
August 18, 2017
Export Citation:
Assignee:
Whitehead Institute for Biomedical Research
International Classes:
C12N15/09; A61K35/12; A61K35/30; A61K35/33; A61K38/47; A61K48/00; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P25/00; A61P25/16; A61P25/28; A61P35/00; A61P37/06; C12N5/10; C12Q1/6881
Domestic Patent References:
| JP2015523856A | 2015-08-20 |
Other References:
NUCLEIC ACIDS RESEARCH (2016) VOL.44, NO.12, PP.5615-5628, JPN6021036420, ISSN: 0004940974
CELL DISCOVERY (2016) VOL.2, NO.16009, PP.1-12, SUPPLEMENTARY FIGURE S1, JPN6021036422, ISSN: 0004940975
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CELL DISCOVERY (2016) VOL.2, NO.16009, PP.1-12, SUPPLEMENTARY FIGURE S1, JPN6021036422, ISSN: 0004940975
BMC CANCER (2011) VOL.11, NO.232, PP.1-11, JPN6022015969, ISSN: 0004940976
BIOCHEM. BIOPHYS. RES. COMMUN. (2010) VOL.394, PP.173-177, JPN6022015968, ISSN: 0004940977
DEVELOPMENTAL BIOLOGY (1996) VOL.177, PP.490-503, JPN6022015967, ISSN: 0004940978
BIOLOGY OPEN (2016) VOL.5, PP.866-874, JPN6021036423, ISSN: 0004758006
TRENDS IN GENETICS (2016) VOL.32, NO.2, PP.101-113, JPN6021036424, ISSN: 0004758007
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto