Title:
NON-HUMAN ANIMALS HAVING HUMANIZED Fcγ RECEPTORS
Document Type and Number:
Japanese Patent JP2020062051
Kind Code:
A
Abstract:
To provide genetically modified mice and methods and compositions for making and using the same, the genetic modification comprising humanization of an FcγRI protein.SOLUTION: The present invention provides an FcγRI protein comprising the extracellular portion of a human FcγRIα chain and the intracellular portion of a mouse FcγRIα chain. In some embodiments, the FcγRIα chain comprises an amino acid sequence at least 90% identical to SEQ ID NO: 5, and the FcγRI protein maintains normal effector functions of the human FcγRI protein. In some embodiments, the extracellular portion of a human FcγRIα chain comprises an EC1 domain, an EC2 domain, an EC3 domain, or a combination thereof. The invention also provides a genomic fragment comprising a nucleic acid molecule that encodes a portion of human FcγRI protein having human extracellular regions and a nucleic acid molecule that encodes an intracellular portion of mouse FcγRI protein.SELECTED DRAWING: None
Inventors:
KEBBEDE ANTENEH
LYNN MACDONALD
GURER CAGAN
KAROLINA A MEAGHER
TU NAXIN
LYNN MACDONALD
GURER CAGAN
KAROLINA A MEAGHER
TU NAXIN
Application Number:
JP2020009985A
Publication Date:
April 23, 2020
Filing Date:
January 24, 2020
Export Citation:
Assignee:
REGENERON PHARMA
International Classes:
C12N15/62; C07K14/735; C07K19/00; C12N5/10; C12N15/12
Domestic Patent References:
| JP2002510973A | 2002-04-09 | |||
| JP2013514778A | 2013-05-02 | |||
| JP2005512574A | 2005-05-12 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita