Title:
DERMIS SPOTS IMPROVER
Document Type and Number:
Japanese Patent JP2020063219
Kind Code:
A
Abstract:
To provide a method for improving spots caused by melanin which exists in dermis.SOLUTION: A method for screening an induction activator of macrophages includes: a process of culturing a macrophage group and a fibroblast group including fibroblasts which performed phagocytosis to melanosome in an isolated manner in the same culture system; a process of adding a test substance to culture medium; and a process of using the travel speed and/or the number of macrophages with respect to the fibroblast group including the fibroblasts which performed phagocytosis to melanosome as an indicator, and determining a test substance having faster travel speed of macrophage and/or a test substance having larger number of macrophages compared to a control as an effective substance.SELECTED DRAWING: Figure 3
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Inventors:
NAKAMURA AYA
YAMAZAKI HIROKO
YAMAZAKI HIROKO
Application Number:
JP2018197298A
Publication Date:
April 23, 2020
Filing Date:
October 19, 2018
Export Citation:
Assignee:
NARIS COSMETICS CO LTD
International Classes:
A61K36/899; A61K8/9794; A61P17/00; A61P43/00; A61Q19/02; G01N33/15; G01N33/50
Domestic Patent References:
| JP2000044485A | 2000-02-15 | |||
| JP2004345969A | 2004-12-09 | |||
| JP2011126850A | 2011-06-30 | |||
| JP2013249265A | 2013-12-12 | |||
| JP2015010070A | 2015-01-19 |
Other References:
有色米オリザノール成分の分析−黒米のオリザノールの特徴−, [ONLINE], 農研機構, [2022.06.17検索], イン, JPN6022025778, ISSN: 0004811680
食品研究部門 研究成果展示会 2017年 展示内容, [ONLINE], 農研機構, [2022.06.17検索], インターネット, <, JPN6022025779, ISSN: 0004811681
食品研究部門 研究成果展示会 2017年 展示内容, [ONLINE], 農研機構, [2022.06.17検索], インターネット, <, JPN6022025779, ISSN: 0004811681