Title:
PRODRUG COMPOUND AND APPLICATION THEREOF
Document Type and Number:
Japanese Patent JP2020073466
Kind Code:
A
Abstract:
To provide a prodrug compound, preparation thereof, and application thereof in treatments of liver diseases or non-liver diseases by intervention in a molecular pathway of liver, or the like.SOLUTION: There is provided a compound of the formula IV, or a stereoisomer or a pharmaceutically acceptable salt thereof. In the formula, Ris H; Zis CRRor the like; Rto Rare specific substituents; M is biological active material, a part of the biological active material, or a prodrug of the biological active material; Xis O or the like; and n is 0, 1, 2, or 3.SELECTED DRAWING: None
Inventors:
QI LIN
Application Number:
JP2019169942A
Publication Date:
May 14, 2020
Filing Date:
September 19, 2019
Export Citation:
Assignee:
LIGAND PHARM INC
International Classes:
C07D317/20; A61K31/357; A61K31/661; A61K45/00; A61K45/06; A61K47/54; A61K49/00; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P5/00; A61P9/00; A61P9/10; A61P31/12; A61P33/00; A61P33/06; A61P35/00; A61P43/00; C07F9/6574; C07F9/6584; C12N5/071; C12N7/06
Domestic Patent References:
| JPH06511246A | 1994-12-15 | |||
| JP2009502790A | 2009-01-29 | |||
| JP2013514973A | 2013-05-02 | |||
| JP2003509428A | 2003-03-11 |
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| WO1984001573A1 | 1984-04-26 | |||
| WO2013002969A1 | 2013-01-03 | |||
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Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto