Title:
METHODS FOR INCREASING RED BLOOD CELL LEVELS AND TREATING INEFFECTIVE ERYTHROPOIESIS BY INHIBITING ACTIVIN B AND/OR GDF11
Document Type and Number:
Japanese Patent JP2020111621
Kind Code:
A
Abstract:
To provide compositions and methods for increasing erythrocytes and/or hemoglobin levels in subjects in need thereof.SOLUTION: The subjects in need include, for example, subjects having an anemia and subjects having an ineffective erythropoietic disorder. In certain aspects, the present disclosure provides a method for increasing red blood cells, treating or preventing anemia, and/or treating or preventing ineffective erythropoiesis in a subject, comprising administering to the patient in need thereof an effective amount of at least an agent or a combination of agents that antagonize (inhibit) activin B and/or GDF11.SELECTED DRAWING: None
Inventors:
RAVINDRA KUMAR
NAGA VENKATA SAI RAJASEKHAR SURAGANI
JOHN KNOFF
NAGA VENKATA SAI RAJASEKHAR SURAGANI
JOHN KNOFF
Application Number:
JP2020077142A
Publication Date:
July 27, 2020
Filing Date:
April 24, 2020
Export Citation:
Assignee:
ACCELERON PHARMA INC
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K31/713; A61K39/395; A61K47/68; A61P7/00; A61P7/06; A61P13/12; A61P35/00; A61P43/00; C07K16/18; C07K16/22; C07K16/46; C07K19/00; C12N15/113
Foreign References:
| WO2013059347A1 | 2013-04-25 | |||
| WO2013164444A1 | 2013-11-07 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita