Title:
METHOD FOR PRODUCING QUINOLINECARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2020158498
Kind Code:
A
Abstract:
To provide a method for industrially advantageously synthesizing a quinolinecarboxylic acid derivative represented by formula (4) or a salt thereof being a production intermediate for a quinolinecarboxamide derivative or a salt thereof.SOLUTION: The method for producing a quinolinecarboxylic acid derivative represented by formula (4) or a salt thereof comprises reacting anilines represented by the following formula (1) with aldehydes represented by formula (2), followed by reacting with α-keto acids represented by formula (3), in the presence of a boron trifluoride-tetrahydrofuran complex or a boron trifluoride-diethyl ether complex. [In the formulae, R1, R2, R3 and R4, which may be the same as or different from each other, are a hydrogen atom, a halogen atom, a lower alkyl group or the like; R5 is a hydrogen atom, a lower alkyl group or the like: and R6 is a hydrogen atom, a lower alkyl group or the like.]SELECTED DRAWING: None
Inventors:
SHIGEYAMA TAKAHIDE
SUGIMOTO TAKUYA
KOMATSU HIDEYUKI
NISHIYAMA HIROYUKI
SUGIMOTO TAKUYA
KOMATSU HIDEYUKI
NISHIYAMA HIROYUKI
Application Number:
JP2020049894A
Publication Date:
October 01, 2020
Filing Date:
March 19, 2020
Export Citation:
Assignee:
YAKULT HONSHA KK
International Classes:
C07D215/52; C07D405/04; C07D409/04; C07D413/14
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
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