Title:
ＨＰＶ１６陽性癌の治療コントロールのための血清検査
Document Type and Number:
Japanese Patent JP2020501162
Kind Code:
A
Abstract:
本発明はＨＰＶ１６陽性癌の治療コントロールのための方法、対応する診断方法における使用のための抗体、ならびに該方法を実施するための検査に関する。特に、本発明は、所定の期間にわたるＨＰＶ１６陽性癌の処置の前後で患者から採取したサンプル中の抗体量の推移をモニターする血清学的方法に関する。さらに、本発明は、キットの形態の免疫学的試験手段を提供し、それを用いて、本発明に係る方法を実施できる。
Inventors:
Hilflich Ralph
Application Number:
JP2019532928A
Publication Date:
January 16, 2020
Filing Date:
December 13, 2017
Export Citation:
Assignee:
Apvillis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
G01N33/574; C07K16/08; C12N7/04; G01N33/543
Domestic Patent References:
| JP2005524076A | 2005-08-11 |
Foreign References:
| US20140356861A1 | 2014-12-04 | |||
| US20130244228A1 | 2013-09-19 |
Other References:
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QINJIAN ZHAO: "Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like an", VIROLOGY JOURNAL, vol. 9, no. 1, JPN6021047539, 2012, pages 52, XP021118932, ISSN: 0004848656, DOI: 10.1186/1743-422X-9-52
ZHAOHUI WANG: "A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological rea", JOURNAL OF GENERAL VIROLOGY, vol. 78, JPN6021047551, 1997, pages 2209 - 2215, XP055635353, ISSN: 0004848657, DOI: 10.1099/0022-1317-78-9-2209
D. SKIBA: "Prognostic Significance of Serum Antibodies to HPV-16 L1 Virus-like Particles in Patients with Invas", ANTICANCER RESEARCH, vol. 26, JPN6021047549, 2006, pages 4921 - 4926, XP055155993, ISSN: 0004848658
KURT HEIM: "Antibodies to human papillomavirus 16 L1 virus-like particles as an independent prognostic marker in", AM J OBSTET GYNECOL, vol. 186, JPN6021047547, 2002, pages 705 - 711, XP002689205, ISSN: 0004848659, DOI: 10.1067/mob.2002.121898
GRIT MEHLHORN: "HPV16-L1-specific Antibody Response Is Associated with Clinical Remission of High-risk HPV-positive", ANTICANCER RESEARCH, vol. 34, JPN6021047544, 2014, pages 5127 - 5132, XP055451826, ISSN: 0005097040
JEAN LACAU ST GUILY: "Human papillomavirus genotype distribution in tonsil cancers", HEAD & NECK ONCOLOGY, vol. 3, no. 1, JPN6021047557, 2011, pages 6, XP021091367, ISSN: 0005097041, DOI: 10.1186/1758-3284-3-6
STEFANIA BELLONE: "Human Papillomavirus Type 16 (HPV-16) Virus-Like Particle L1-Specific CD8+ Cytotoxic T Lymphocytes (", JOURNAL OF VIROLOGY, vol. 83, no. 13, JPN6021047555, 2009, pages 6779 - 6789, XP055613278, ISSN: 0005097042, DOI: 10.1128/JVI.02443-08
MARLOES L. H. DE BRUIJN: "L1-Specific Protection from Tumor Challenge Elicited by HPV16 Virus-like Particles", VIROLOGY, vol. 250, JPN6021047556, 1998, pages 371 - 376, XP004445606, ISSN: 0005097043, DOI: 10.1006/viro.1998.9372
MARKUS SCHMITT: "Diagnosing Cervical Cancer and High-Grade Precursors by HPV16 Transcription Patterns", CANCER RES;, vol. 70, no. 1, JPN6021047552, 2010, pages 249 - 256, XP002638848, ISSN: 0005097044, DOI: 10.1158/0008-5472.CAN-09-2514
THOMAS WEILANDA: "DRH1 - a novel blood-based HPV tumour marker", EBIOMEDICINE, vol. 56, JPN6023027448, 2020, pages 102804, ISSN: 0005097045
TANJA D. DE GRUIJL: "Immunoglobulin G Responses Against Human Papillomavirus Type 16 Virus-Like Particles in a Prospectiv", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 89, no. 9, JPN6021047545, 1997, pages 630 - 638, ISSN: 0005097037
HIROYUKI OCHI: "Do Neutralizing Antibody Responses Generated by Human Papillomavirus Infections Favor a Better Outco", JOURNAL OF MEDICAL VIROLOGY, vol. 84, JPN6021047542, 2012, pages 1128 - 1134, XP055452255, ISSN: 0005097038, DOI: 10.1002/jmv.23258
EVA KOSLABOVA: "Markers of HPV infection and survival in patients with head and neck tumors", INTERNATIONAL JOURNAL OF CANCER, vol. 133, JPN6021047541, 2013, pages 1832 - 1839, XP071287386, ISSN: 0005097039, DOI: 10.1002/ijc.28194
Attorney, Agent or Firm:
Shinichiro Tanaka
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori