Title:
トランスフェリン受容体トランスジェニックモデル
Document Type and Number:
Japanese Patent JP2020510418
Kind Code:
A
Abstract:
いくつかの態様では、本発明は、キメラトランスフェリン受容体（ＴｆＲ）ポリヌクレオチド及びポリペプチドを提供する。他の態様では、本発明は、キメラＴｆＲトランスジェニック動物モデル、及び血液脳関門を通過できる治療薬を同定するために前記動物モデルを使用する方法を提供する。【選択図】なし
Inventors:
Dennis Mark S.
Silberman Adam P.
Zucello Joyu
Silberman Adam P.
Zucello Joyu
Application Number:
JP2019545322A
Publication Date:
April 09, 2020
Filing Date:
February 15, 2018
Export Citation:
Assignee:
Denali Therapeutics Inc.
International Classes:
C12N15/62; A01K67/027; C12N5/0735; C12N5/10; C12Q1/02; C12Q1/68
Domestic Patent References:
| JP2016526878A | 2016-09-08 | |||
| JP2020508053A | 2020-03-19 |
Foreign References:
| WO2016081643A1 | 2016-05-26 |
Other References:
YU Y J; ET AL: "THERAPEUTIC BISPECIFIC ANTIBODIES CROSS THE BLOOD-BRAIN BARRIER IN NONHUMAN PRIMATES", SCIENCE TRANSLATIONAL MEDICINE, vol. 6, JPN5020003769, 5 November 2014 (2014-11-05), US, pages 261 - 154, XP055252027, ISSN: 0004973721, DOI: 10.1126/scitranslmed.3009835
J. VIROL.，2012，VOL. 86, NO. 7，PP.4024-4028, JPN6022032870, ISSN: 0004973722
TAKETOSHI MIZUTANI; AYA ISHIZAKA; COH-ICHI NIHEI: "TRANSFERRIN RECEPTOR 1 FACILITATES POLIOVIRUS PERMEATION OF MOUSE BRAIN CAPILLARY ENDOTHELIAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. VOL:291, NR:6, JPN5020003803, 5 February 2016 (2016-02-05), US, pages 2829 - 2836, ISSN: 0004844234
J BIOL CHEM, 2006 APR 14, VOL. 281, NO. 15, PP. 10243-10249, JPN6022001569, ISSN: 0004844235
J. VIROL.，2012，VOL. 86, NO. 7，PP.4024-4028, JPN6022032870, ISSN: 0004973722
TAKETOSHI MIZUTANI; AYA ISHIZAKA; COH-ICHI NIHEI: "TRANSFERRIN RECEPTOR 1 FACILITATES POLIOVIRUS PERMEATION OF MOUSE BRAIN CAPILLARY ENDOTHELIAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. VOL:291, NR:6, JPN5020003803, 5 February 2016 (2016-02-05), US, pages 2829 - 2836, ISSN: 0004844234
J BIOL CHEM, 2006 APR 14, VOL. 281, NO. 15, PP. 10243-10249, JPN6022001569, ISSN: 0004844235
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto