Title:
診断用終末糖化産物抗体
Document Type and Number:
Japanese Patent JP2020521117
Kind Code:
A
Abstract:
患者における細胞老化と関連した疾患、障害又は病的状態を診断する方法は、患者から試料を得るステップと、試料中の細胞表面ＡＧＥを示す細胞の数を測定するステップと、試料中の細胞表面ＡＧＥを示す細胞の数が、対照における細胞表面ＡＧＥを示す細胞の数より大きい場合、患者を細胞老化と関連した疾患、障害又は病的状態と診断するステップとを含む。
Inventors:
Gruber Luis S.
Application Number:
JP2019560086A
Publication Date:
July 16, 2020
Filing Date:
May 03, 2018
Export Citation:
Assignee:
Wrinkle corporation
International Classes:
G01N33/48; A61K31/352; A61K31/506; A61K39/395; A61K45/00; A61K47/55; A61K47/68; A61P1/04; A61P3/10; A61P7/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P39/02; A61P43/00; C12Q1/02; G01N33/53
Domestic Patent References:
| JP2003160599A | 2003-06-03 | |||
| JP2013533766A | 2013-08-29 |
Foreign References:
| US20160215043A1 | 2016-07-28 | |||
| US20110319499A1 | 2011-12-29 | |||
| WO2016040752A1 | 2016-03-17 |
Other References:
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MEERWALDT, R. ET AL.: "Skin autofluorescence is a strong predictor of cardiac mortality in diabetes", DIABETES CARE, vol. 30, no. 1, JPN6022051419, January 2007 (2007-01-01), pages 107 - 112, XP055488237, ISSN: 0004941518, DOI: 10.2337/dc06-1391
NI JIAQIAN ET AL.: "Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration", MOLECULAR & CELLULAR PROTEOMICS, vol. 8, JPN6020015471, 2009, pages 1921 - 1933, XP055292726, ISSN: 0004731615, DOI: 10.1074/mcp.M900127-MCP200
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Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita