Title:
METHOD FOR PRODUCING ESTER COMPOUND
Document Type and Number:
Japanese Patent JP2021004232
Kind Code:
A
Abstract:
To industrially advantageously produce a t-butyl ester of 11-oxo-6,11-dihydrodibenz [b, e] oxepin-2-acetic acid as an intermediate for producing olopatadine.SOLUTION: A t-butyl ester of 11-oxo-6,11-dihydrodibenz [b, e] oxepin-2-acetic acid can be produced by reacting 11-oxo-6,11-dihydrodibenz [b, e] oxepin-2-acetic acid, t-butyl alcohol and di-t-butyl dicarbonate in the presence of one or more bases selected from dimethylaminopyridine or N-methylimidazole and triethylamine, pyridine, diisopropylethylamine and dimethylaniline. Furthermore, olopatadine can be produced by a reaction with 3-dimethylaminopropyl magnesium chloride, a dehydration reaction, and a deesterification reaction.SELECTED DRAWING: None
Inventors:
IWASAKI MITSUHIRO
AIKAWA TOSHIAKI
HIDA SANAE
AIKAWA TOSHIAKI
HIDA SANAE
Application Number:
JP2020040577A
Publication Date:
January 14, 2021
Filing Date:
March 10, 2020
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07D313/12
Attorney, Agent or Firm:
Toru Nakayama
Toru Sakamoto
Toru Sakamoto