Title:
PYRIDINE CARBONYL DERIVATIVE AND THERAPEUTIC USE THEREOF AS TRPC6 INHIBITOR
Document Type and Number:
Japanese Patent JP2021008503
Kind Code:
A
Abstract:
To provide a pharmaceutical composition for use in the treatment of a disease or disorder that can be alleviated by TRPC6 inhibition, such as cardiac hypertrophy, ischemia, ischemic reperfusion injury, hypertension, pulmonary arterial hypertension, idiopathic pulmonary arterial hypertension, restenosis, chronic obstructive pulmonary disease, cystic fibrosis, Alzheimer's disease, and Parkinson's disease.SOLUTION: A pharmaceutical composition comprises pyridine carbonyl derivatives, for example, a reaction product as follows: [4-(6-amino-4-methyl-pyridazine-3-yl)-piperidine-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridine-2-yl]-methanone, and the like.SELECTED DRAWING: None
Inventors:
THIERRY BOUYSSOU
DIRK GOTTSCHLING
NIKLAS HEINE
LANA LOUISE SMITH KEENAN
MICHAEL D LOWE
HOSSEIN RAZAVI
CHRISTOPHER RONALD SARKO
SIMON SURPRENANT
TAKAHASHI SHUSUKE
TURNER MICHAEL R
WU XINYUAN
DIRK GOTTSCHLING
NIKLAS HEINE
LANA LOUISE SMITH KEENAN
MICHAEL D LOWE
HOSSEIN RAZAVI
CHRISTOPHER RONALD SARKO
SIMON SURPRENANT
TAKAHASHI SHUSUKE
TURNER MICHAEL R
WU XINYUAN
Application Number:
JP2020170563A
Publication Date:
January 28, 2021
Filing Date:
October 08, 2020
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT
HYDRA BIOSCIENCES LLC
HYDRA BIOSCIENCES LLC
International Classes:
C07D401/14; A61K31/501; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/14; A61P13/12; A61P19/02; A61P21/02; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2021500390A | 2021-01-07 | |||
| JP2003064057A | 2003-03-05 | |||
| JP2016520105A | 2016-07-11 |
Foreign References:
| WO2016138114A1 | 2016-09-01 |
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai