Title:
ANTIBODY-DRUG CONJUGATE
Document Type and Number:
Japanese Patent JP2021052791
Kind Code:
A
Abstract:
To provide a composition for delivering a drug to muscle.SOLUTION: The present invention relates to a conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof (e.g. Fab') with a drug, and a composition comprising the conjugate for delivering a drug to a tissue or a cell of muscle or the like.SELECTED DRAWING: None
Inventors:
SUGO TSUKASA
MIYATA KENICHI
OTAKI TETSUYA
MIYATA KENICHI
OTAKI TETSUYA
Application Number:
JP2020211507A
Publication Date:
April 08, 2021
Filing Date:
December 21, 2020
Export Citation:
Assignee:
GENAHEAD BIO INC
International Classes:
C12N15/13; A61K31/7088; A61K31/7105; A61K39/395; A61K47/68; A61K48/00; A61P9/00; A61P21/00; C07K16/28; C07K16/46; C12N15/11; C12N15/113; C12N15/62
Other References:
NORMAND-SDIQUI N, AKHTAR S: "Oligonucleotide delivery: Uptake of rat transferrin receptor antibody (OX-26) conjugates into an in", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. Vol.163, No.1-2, JPN7019002443, 1998, pages 63 - 71, ISSN: 0004650557
HUDSON AJ ET AL.: "Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 182, no. 1, JPN7019002444, 1999, pages 49 - 58, XP000997331, ISSN: 0004650558, DOI: 10.1016/S0378-5173(99)00062-9
JOERGER, R. D. ET AL.: "Analyte detection with DNA-labeled antibodies and polymerase chain reaction", CLINICAL CHEMISTRY, vol. 41, no. 9, JPN6021046893, 1995, pages 1371 - 1377, ISSN: 0004650559
ALLEN, R. C. ET AL.: "An immuno-PCR method for detecting Bacillus thuringiensis Cry1Ac toxin", JOURNAL OF IMMUNOLOGICAL METHODS, vol. Vol.308, No.1-2, JPN6021046892, 2006, pages 109 - 115, ISSN: 0004650560
宮田 完二郎 ほか: "高分子ナノテクノロジーが切り拓く核酸医薬デリバリー", DRUG DELIVERY SYSTEM, vol. 第３１巻，第１号, JPN7019002449, January 2016 (2016-01-01), pages 44 - 53, ISSN: 0004650561
MENDONCA, L. S. ET AL.: "Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloi", BIOCONJUGATE CHEMISTRY, vol. 21, no. 1, JPN6021046891, 2010, pages 157 - 168, XP002641524, ISSN: 0004650562
HUDSON AJ ET AL.: "Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 182, no. 1, JPN7019002444, 1999, pages 49 - 58, XP000997331, ISSN: 0004650558, DOI: 10.1016/S0378-5173(99)00062-9
JOERGER, R. D. ET AL.: "Analyte detection with DNA-labeled antibodies and polymerase chain reaction", CLINICAL CHEMISTRY, vol. 41, no. 9, JPN6021046893, 1995, pages 1371 - 1377, ISSN: 0004650559
ALLEN, R. C. ET AL.: "An immuno-PCR method for detecting Bacillus thuringiensis Cry1Ac toxin", JOURNAL OF IMMUNOLOGICAL METHODS, vol. Vol.308, No.1-2, JPN6021046892, 2006, pages 109 - 115, ISSN: 0004650560
宮田 完二郎 ほか: "高分子ナノテクノロジーが切り拓く核酸医薬デリバリー", DRUG DELIVERY SYSTEM, vol. 第３１巻，第１号, JPN7019002449, January 2016 (2016-01-01), pages 44 - 53, ISSN: 0004650561
MENDONCA, L. S. ET AL.: "Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloi", BIOCONJUGATE CHEMISTRY, vol. 21, no. 1, JPN6021046891, 2010, pages 157 - 168, XP002641524, ISSN: 0004650562
Attorney, Agent or Firm:
Seiji Ohno
Yuko Matsuniya
Umeda Shinsuke
Tomoe Konno
Nobuto Oki
Yuko Matsuniya
Umeda Shinsuke
Tomoe Konno
Nobuto Oki