Title:
CHECKPOINT BLOCKADE AND MICROSATELLITE INSTABILITY
Document Type and Number:
Japanese Patent JP2021095410
Kind Code:
A
Abstract:
To provide methods for treating cancer patients.SOLUTION: Provided is a pharmaceutical composition for administering to a cancer patient to treat a cancer patient, which comprises an immune checkpoint inhibitory antibody which blocks immune checkpoint, such as cytotoxicity T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1), the cancer is selected from the group consisting of colon cancer, stomach cancer, endometrial cancer, bile duct cancer, pancreatic cancer, and prostate cancer, and the cancer patient having a microsatellite instable cancer (MSI).SELECTED DRAWING: None
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Inventors:
LUIS DIAZ
BERT VOGELSTEIN
KINZLER KENNETH W
NICKOLAS PAPADOPOULOS
LE DUNG
PARDOLL DREW M
TOPALIAN SUZANNE L
BERT VOGELSTEIN
KINZLER KENNETH W
NICKOLAS PAPADOPOULOS
LE DUNG
PARDOLL DREW M
TOPALIAN SUZANNE L
Application Number:
JP2021032226A
Publication Date:
June 24, 2021
Filing Date:
March 02, 2021
Export Citation:
Assignee:
UNIV JOHNS HOPKINS
International Classes:
A61K39/395; A61P35/00; A61P37/04; G01N33/574
Domestic Patent References:
| JP2005518798A | 2005-06-30 |
Foreign References:
| WO2013190555A1 | 2013-12-27 |
Other References:
LE, D.T. ET AL., J CLIN ONCOL, vol. Vol.32, No.15, Suppl.1, JPN6018006472, May 2014 (2014-05-01), pages 3128, ISSN: 0004894993
LIOSA, N.J. ET AL., J CLIN ONCOL, vol. Vol.32, No.15, Suppl.1, JPN6018006473, May 2014 (2014-05-01), pages 3620, ISSN: 0004894994
GATALICA, Z. ET AL., J CLIN ONCOL, vol. Vol.32, No.15, Suppl.1, JPN6018006476, May 2014 (2014-05-01), pages 3625, ISSN: 0004894995
DAVIS, J.L. ET AL., ARCH PATHOL LAB MED, vol. 138, JPN6018006478, June 2014 (2014-06-01), pages 823 - 7, ISSN: 0004894996
LIOSA, N.J. ET AL., J CLIN ONCOL, vol. Vol.32, No.15, Suppl.1, JPN6018006473, May 2014 (2014-05-01), pages 3620, ISSN: 0004894994
GATALICA, Z. ET AL., J CLIN ONCOL, vol. Vol.32, No.15, Suppl.1, JPN6018006476, May 2014 (2014-05-01), pages 3625, ISSN: 0004894995
DAVIS, J.L. ET AL., ARCH PATHOL LAB MED, vol. 138, JPN6018006478, June 2014 (2014-06-01), pages 823 - 7, ISSN: 0004894996
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto