Title:
OCULAR FORMULATIONS FOR DRUG DELIVERY AND PROTECTION OF ANTERIOR SEGMENT OF EYE
Document Type and Number:
Japanese Patent JP2021121624
Kind Code:
A
Abstract:
To provide formulations and the use thereof for ocular delivery of topical therapeutic agents for treating ocular angiogenesis, which accomplish the combined effects of decreasing corneal and anterior segment drug exposure and protecting corneal and anterior segment tissues, while increasing posterior segment bioavailability.SOLUTION: The present invention provides topical formulations comprising: the compound represented by the formula in the figure or its free base; and a second active agent selected from nicotinic acid, nicotinamide and vitamin K. The present invention also provides pharmaceutical compositions comprising the compound or its free base, and suspensions comprising particle compositions of the compound or its free base.SELECTED DRAWING: Figure 6B
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Inventors:
DAVID P BINGAMAN
PAUL G CHANEY
MARTIN B WAX
PAUL G CHANEY
MARTIN B WAX
Application Number:
JP2021086698A
Publication Date:
August 26, 2021
Filing Date:
May 24, 2021
Export Citation:
Assignee:
PANOPTICA INC
International Classes:
A61K31/427; A61K9/10; A61K31/122; A61K31/455; A61K47/10; A61K47/26; A61K47/32; A61K47/34; A61K47/38; A61P27/02; A61P43/00
Domestic Patent References:
| JP6657193B2 | 2020-03-04 |
Foreign References:
| US20050074497A1 | 2005-04-07 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office