Title:
【発明の名称】HTLV-▲III▼GAG/ENV遺伝子蛋白質の発現と精製
Document Type and Number:
Japanese Patent JP2625118
Kind Code:
B2
Abstract:
Methods and compositions are provided for the cloning and expression of plasmids bearing genes encoding a novel protein derived from HTLV-III. This protein, which is called the gag/env protein and which contains antigenic determinants from both the core and envelope proteins of HTLV-III, can be purified to homogeneity and used as the basis for diagnostic tests to detect the presence of antibodies against viruses associated with AIDS or the viruses themselves in human sera and other biological fluids. The gag/env protein may also be formulated for use as a vaccine for protection against AIDS through prophylactic immunization.
Inventors:
Robert Mitchell Crawl
Dal Young
Dal Young
Application Number:
JP8219787A
Publication Date:
July 02, 1997
Filing Date:
April 02, 1987
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07K16/00; A61K39/21; C07K14/00; C07K14/16; C07K19/00; C12N1/20; C12N1/21; C12N15/00; C12N15/09; C12N15/18; C12N15/48; C12N15/49; C12P21/02; C12Q1/70; G01N33/534; G01N33/569; G01N33/577; A61K38/00; A61K39/00; C12N15/63; C12R1/19; (IPC1-7): C12P21/02; A61K39/21; C07K14/15; C12N15/09; G01N33/534; G01N33/569; G01N33/577
Domestic Patent References:
| JP6067859A |
Other References:
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Ｓｃｉｅｎｃｅ，Ｖｏｌ．２２８，（５Ａｐｒｉｌ １９８５），Ｐ．９３−９６
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Attorney, Agent or Firm:
Akira Asamura (2 outside)