Title:
【発明の名称】修飾メニンゴコツクス多糖複合ワクチン
Document Type and Number:
Japanese Patent JP2637845
Kind Code:
B2
Abstract:
Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.
Inventors:
JENINGUSU HARORUDO JEI
MAIKON FURANSHISU
MAIKON FURANSHISU
Application Number:
JP50090891A
Publication Date:
August 06, 1997
Filing Date:
December 13, 1990
Export Citation:
Assignee:
NASHONARU RISAACHI KAUNSHIRU OBU KANADA
International Classes:
A61K39/00; A61K39/02; A61K39/095; A61K39/108; A61K39/385; A61K39/395; A61P31/04; C07K16/12; C08B37/00; C12P19/04; A61K38/00; (IPC1-7): A61K39/095; A61K39/385; A61K39/395; C08B37/00
Attorney, Agent or Firm:
Heiyoshi Odashima