【発明の名称】ワクチンにおける,または関する改良

Title:

【発明の名称】ワクチンにおける,または関する改良

Document Type and Number:

Japanese Patent JP2690620

Kind Code:

B2

Abstract:

PCT No. PCT/GB93/00716 Sec. 371 Date Jan. 5, 1995 Sec. 102(e) Date Jan. 5, 1995 PCT Filed Apr. 6, 1993 PCT Pub. No. WO93/19781 PCT Pub. Date Oct. 14, 1993Non-ionic surfactant vesicles (NSIV) with entrapped antigen act as potent immunological adjuvants and can produce antibody titers of the same order of magnitude as those using Freund's Complete Adjuvant. The invention provides vaccines comprising such vesicles. Preferably non-ionic surfactants are glycerol esters particularly 1-monopalmitoyl glycerol. The vesicles may be administered by injection or via the mucosal route, oral administration being preferred.

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Inventors:

Alexander, james
Breeware, James McDonald

Application Number:

JP51726993A

Publication Date:

December 10, 1997

Filing Date:

April 06, 1993

Export Citation:

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Assignee:

Prochus Molecular Design Limited

International Classes:

A61K9/08; A61K9/00; A61K9/127; A61K39/00; A61K39/39; C07K7/23; C07K14/12; C07K14/45; (IPC1-7): A61K39/00; A61K9/08

Domestic Patent References:

JPS63501078A	1988-04-21
JPS6323737A	1988-02-01

Foreign References:

EP0293530A2

1988-12-07

Attorney, Agent or Firm:

Shunichiro Suzuki

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