【発明の名称】2-アリールプロピオン酸の製造方法

Japanese Patent JP2702915

B2

A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R₁ represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula wherein R₂ is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.

Mauro Attilio Beltra
Arthur Friedrich Marx
Hein Simon Coher
Wilhelms Johannes Cwax
Cornelis Jacobs van der Laken
Girlless Thomas Phillips
Brian william robertson
Peter Douglas Watts

JP155887A

January 26, 1998

January 07, 1987

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Gist Brocades-Muro-Ze Fuenno-Tochiyup
Shell International Research Marchuppie Besloten Fennaught Chap

A61K31/19; A61K31/33; A61P25/04; A61P29/00; C07C57/30; C07D209/46; C07H21/04; C12N1/20; C12N1/21; C12N9/16; C12N9/18; C12N15/00; C12P7/40; C12P17/00; C12P41/00; C12N15/09; C12R1/06; C12R1/10; C12R1/125; C12R1/19; C12R1/38; C12R1/385; C12R1/39; C12R1/40; C12R1/465; C12R1/785; C12N; (IPC1-7): C12P41/00

JPS60145096A
JPS62190097A

Minoru Nakamura (3 others)

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