Title:
【発明の名称】アンスラサイクリン誘導体のリポソーム組成物
Document Type and Number:
Japanese Patent JP2716178
Kind Code:
B2
Abstract:
Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of anthracyclines, the 4-demethoxy-3'-desamino-2'-iodo analogs, shown to have extremely high incorporatio efficiencies of greater than 95%. These liposomes demonstrate an improved antitumor efficacy, with much reduced toxicity, against accepted tumor models, and further exhibit excellent stability upon storage, for example, in the form of a dried powder.
Inventors:
Perez-Solar, Roman
Pribe, Waldmar
Gabriel, Lopez-Belestein
Pribe, Waldmar
Gabriel, Lopez-Belestein
Application Number:
JP50483388A
Publication Date:
February 18, 1998
Filing Date:
May 18, 1988
Export Citation:
Assignee:
Board of Regents, The University of Texas System
International Classes:
A61K9/127; A61K31/203; A61K31/70; C07H15/252; A61K31/7028; A61K31/7034; A61K31/704; A61P35/00; (IPC1-7): A61K31/71; A61K9/127
Domestic Patent References:
| JP61293910A | ||||
| JP6287514A |
Other References:
【文献】米国特許4537882(US,A)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)