Title:
【発明の名称】ラジカル仲介性細胞損傷の予防及び治療のためのフェノール性A環構造を有するステロイドの使用
Document Type and Number:
Japanese Patent JP2845625
Kind Code:
B2
Abstract:
The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being. The at least one steroid is selected from the group consisting of ent-estradiol, 17alpha-estradiol, 8-dehydro-estradiol, 8-dehydro-17alpha-estradiol, 8(14)-dehydroestradiol, 6,8-didehydro-17alpha-estradiol, 6-dehydroestriol, 9(11)-dehydroestriol, 20-hydroxymethyl-3-hydroxy-19-norpregna-1,3,5(10)-triene, 14alpha, 15alpha-methylene-8-dehydroestradiol, 14alpha, 15alpha-methylene-estradiol, 2-hydroxy-estradiol-3-methyl ether, 3-hydroxy-1,3,5(10)-estratriene-17S-spirooxirane, 3-hydroxy-1,3,5(10),9(11)-estratetraene-17S-spirooxirane, and 14beta,15beta-methylene-8-dehydroestradiol. This method strongly inhibits changes in cells and tissues, such as lipid peroxidation and oxidation of low-density lipoprotein (LDL) cholesterol, triggered by reaction oxygen species, free oxygen radicals and other forms of radicals and thus reduces attendant irreversible membrane and endothelial damage.
Inventors:
DOROESHAA PEETAA
MENZENBATSUHA BERUNTO
HONSORUDO KURUTO
UNDOITSU BERUNTO
OETERU MIHYAERU
REEMAA BORUFUGANGU
KAUFUMAN GYUNTAA
SHUREEDAA IENSU
MENZENBATSUHA BERUNTO
HONSORUDO KURUTO
UNDOITSU BERUNTO
OETERU MIHYAERU
REEMAA BORUFUGANGU
KAUFUMAN GYUNTAA
SHUREEDAA IENSU
Application Number:
JP51352795A
Publication Date:
January 13, 1999
Filing Date:
November 08, 1994
Export Citation:
Assignee:
IENAFUARUMU GMBH
International Classes:
A61K31/565; A61K31/575; C07J1/00; (IPC1-7): A61K31/565; A61K31/575; C07J1/00
Attorney, Agent or Firm:
Nobuto Watanabe (1 person outside)