Title:
【発明の名称】薬剤スクリーニングアッセイ
Document Type and Number:
Japanese Patent JP2846433
Kind Code:
B2
Abstract:
Compounds are evaluated for their binding to naturally occurring receptors, by employing the natural ligand conjugated to an enzyme donor fragment of beta -galactosidase for competing with the sample compound for the natural acceptor binding site or in the absence of competition where the sample compound binds to an allosteric site. By adding the enzyme acceptor fragment of the beta -galactosidase and substrate, the binding affinity of the sample compound may be evaluated as a measure of agonist or antagonist capability.
Inventors:
PYAARU KANNA
Application Number:
JP21380190A
Publication Date:
January 13, 1999
Filing Date:
August 14, 1990
Export Citation:
Assignee:
BEERINGAA MANHAIMU CORP
International Classes:
G01N33/53; G01N33/535; G01N33/542; G01N33/78; G01N33/82; (IPC1-7): G01N33/53; G01N33/542
Other References:
【文献】欧州公開310430(EP,A1)
Attorney, Agent or Firm:
Aoki Akira (2 outside)