Title:
【発明の名称】15-デオキシスペルグアリン類似体、その製造方法および治療薬
Document Type and Number:
Japanese Patent JP2860778
Kind Code:
B2
Abstract:
15-Deoxy-spergualin carbamate analogues of formula NH2-C(=NH)NH(CH2)6ACH2NHCO-O-(CH2)4NH(CH2)2-*CH(R)-NH2 (I) and their addn. salts are new. A=CONH or NHCO; R=H or Me; if R is other than H, *C has (R,S) or (R) configuration. Intermediates of formulae NHR1-C(=NR1)NH(CH2)6ACH2NHCO-O-(CH2)4N(R1)(CH2) 2-*CH(R)-NHR1 (II) and HO-(CH2)4-NR1-(CH2)2-*CH(R)-NHR1 (III; R=Me) are also new.
Inventors:
RUBURETON RYUTSUKU
RUNOO PATORISU
DEYUMA KURISUCHIINU
RUNOO PATORISU
DEYUMA KURISUCHIINU
Application Number:
JP14838496A
Publication Date:
February 24, 1999
Filing Date:
May 17, 1996
Export Citation:
Assignee:
FURUNIE IND E SANTE
International Classes:
A61K31/155; A61K31/16; A61K38/06; A61P33/02; A61P33/06; A61K31/27; A61P37/06; C07C215/14; C07C271/20; C07C277/08; C07C279/12; C07C279/14; C07C279/24; C07K1/06; C07K5/09; (IPC1-7): C07C279/12; A61K31/27; C07C277/08; C07C279/24
Attorney, Agent or Firm:
Maejima Hajime