Title:
【発明の名称】イミダゾール誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP2864292
Kind Code:
B2
Abstract:
PCT No. PCT/KR95/00058 Sec. 371 Date Nov. 13, 1996 Sec. 102(e) Date Nov. 13, 1996 PCT Filed May 19, 1995 PCT Pub. No. WO95/32198 PCT Pub. Date Nov. 30, 1995Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: (I) wherein: A is a straight, branched or cyclic C1-C6 alkyl group, or OR1 wherein R1 is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical; B is a halogen, CF3 or CF2CF3; X is N or N-oxide; Y is -CH2-, -CH(OR1)- wherein R1 is the same as defined above, or -C(=O)-; n is 0 or an integer of 1 to 4; Z is a halogen, -OH, -OR1, -NR1R2, -N(=O)R3R4, -C(=O)R1, -C(=O)OR1, -CH(OR1)2 or -C(=O)N1N2 wherein R1 is the same as defined above, R2 is, independently of R1, a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical, and R3 and R4 are independently a straight, branched or cyclic C1-C6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical.
Inventors:
YUU SONGU UN
II KYU YANGU
RII SANGU HII
KIMU HEE RYONGU
SOO JII HII
KIMU NATSUKU JONGU
KIMU SON JU
CHAA OKU JA
SHIN YONGU AA
SHIN HOA SOTSUPU
RII SUNGU HOO
JONGU II SUKU
RII BOYONGU HOO
SOO HOO UON RI
II KYU YANGU
RII SANGU HII
KIMU HEE RYONGU
SOO JII HII
KIMU NATSUKU JONGU
KIMU SON JU
CHAA OKU JA
SHIN YONGU AA
SHIN HOA SOTSUPU
RII SUNGU HOO
JONGU II SUKU
RII BOYONGU HOO
SOO HOO UON RI
Application Number:
JP53020895A
Publication Date:
March 03, 1999
Filing Date:
May 19, 1995
Export Citation:
Assignee:
KORIA RISAACHI INST OBU CHEM TEKUNOROJII
International Classes:
A61K31/44; A61K31/4427; A61P9/12; A61P43/00; C07D401/14; (IPC1-7): C07D401/14; A61K31/44
Attorney, Agent or Firm:
Oka Saki Hideo