Title:
【発明の名称】第▲VIII▼:C因子活性を有するタンパク質複合体およびその製法
Document Type and Number:
Japanese Patent JP2865861
Kind Code:
B2
Abstract:
Recombinant protein complexes having human Factor VIII:C activity are produced in a eukaryotic host cell by expressing a DNA construct encoding said protein complex joined in reading frame with control sequences providing for the expression of said DNA construct in said host cell, wherein said DNA construct comprises a nucleotide sequence that encodes a first polypeptide homologous to the A domain of human Factor VIII:C linked to a second polypeptide homologous to the C domain of human Factor VIII:C by a polypeptide spacer, wherein the polypeptide spacer is other than the full length B domain of human Factor VIII:C and comprises an amino acid sequence homologous to a human Ig heavy chain hinge region.
Inventors:
CHAPUMAN BAABARA
BAAKU RAE RIN
RASUMUTSUSEN MIRERA ESUBAN
MITSUKERUSEN YAN MEERAA
BAAKU RAE RIN
RASUMUTSUSEN MIRERA ESUBAN
MITSUKERUSEN YAN MEERAA
Application Number:
JP50006891A
Publication Date:
March 08, 1999
Filing Date:
November 15, 1990
Export Citation:
Assignee:
NOBO NORUDEISUKU AS
CHIRON CORP
CHIRON CORP
International Classes:
A61K38/43; A61P7/00; A61P7/02; C07H21/04; C12N15/09; C07K7/06; C07K14/00; C07K14/745; C07K14/755; C07K14/81; C07K16/00; C07K19/00; C12N5/10; C12N15/12; C12N15/62; C12N15/85; C12P21/02; A61K38/00; C12R1/91; C07K; C12N; C12P; (IPC1-7): C12P21/02; C12N5/10; C12N15/09
Domestic Patent References:
| JP62282594A | ||||
| JP63503275A |
Attorney, Agent or Firm:
Hidesaku Yamamoto