Title:
【発明の名称】6位にスレオニンを有するソマトスタチン類縁体オクタペプチド
Document Type and Number:
Japanese Patent JP2925321
Kind Code:
B2
Abstract:
A compound of the formula: wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkinyl, phenyl, naphthyl, or C7-10 phenylalkyl), or R2OCO (where R2 is C1-10 alkyl or C7-10 phenylalkyl), provided that when one of A1 or A2 is R1CO or R2OCO, the other must be H; each X1 and X2, independently, is H, F, Cl, Br, OH, CH3, or CF3, provided that at least one of X1 and X2 must be H; A3 is Phe or Tyr; and A4 is OH, NH2, or NH-R3 (wherein R3 is a saturated aliphatic C1-8 alkyl); or a pharmaceutically acceptable salt thereof. A therapeutic composition containing the compound of the present invention and a method of using the same are also described.
Inventors:
KOI DEEBITSUTO EICHI
MAAFUII UIRIAMU EI
MAAFUII UIRIAMU EI
Application Number:
JP50158490A
Publication Date:
July 28, 1999
Filing Date:
December 04, 1990
Export Citation:
Assignee:
ADOMINISUTOREETAAZU OBU ZA TSUUREIN EDEYUKEISHONARU FUANDO
International Classes:
A61K31/00; A61P5/00; A61K38/04; A61P5/02; C07K14/575; C07K14/655; A61K38/00; (IPC1-7): C07K14/655; A61K31/00; A61K38/04
Other References:
【文献】米国特許4853371(US,A)
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)