【発明の名称】ベンゾピランおよびベンゾ縮合化合物、それらの製造、並びにロイコトリエンB▲下4▼(LTB▲下4▼)アンタゴニストとしてのそれらの用途

Title:

Document Type and Number:

Japanese Patent JP3012339

Kind Code:

B2

Abstract:

This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, and to a method of using such compounds as LTB4 antagonists. The compounds of this invention inhibit the action of LTB4 and are therefore useful in the treatment of LTB4 induced illnesses such as inflammatory disorders including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, psoriasis and other skin disorders such as eczema, erythema, pruritus and acne, stroke and other forms of reperfusion injury, graft rejection, autoimmune diseases, asthma, and other conditions where marked neutrophil infiltration occurs.

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Inventors:

Dombroski, Mark A.
Cook, kevin
Anthony Daniel, Piscopio

Application Number:

JP51305696A

Publication Date:

February 21, 2000

Filing Date:

May 26, 1995

Export Citation:

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Assignee:

Pfizer Inc.

International Classes:

A61K31/19; A61K31/215; A61K31/34; A61K31/343; A61K31/35; A61K31/352; A61P11/00; A61P29/00; A61P37/08; A61P43/00; C07C45/46; C07C45/62; C07C45/67; C07C45/74; C07C63/72; C07C311/09; C07D307/83; C07D311/22; C07D407/04; C07D409/04; (IPC1-7): C07D311/22; A61P11/00; A61P29/00; A61P37/08; A61P43/00; A61K31/35

Other References:

【文献】国際公開93/15066(WO,A1)
【文献】国際公開93/15067(WO,A1)
【文献】仏国特許公開2257282(FR,A1)

Attorney, Agent or Firm:

Kazuo Shamoto (4 outside)

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