Title:
【発明の名称】芳香族ジアミン誘導体及びその製造方法
Document Type and Number:
Japanese Patent JP3048590
Kind Code:
B2
Abstract:
NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H, substituted or unsubstituted alkyl or R1 and R2 link with ethylene to form a heterocyclic ring; R3 is H or carboxylic acid ester; Z is CH or N; Ar is chloro- substituted or unsubstituted phenyl or pyridyl). EXAMPLE:N-[2-(4-Chlorocinnamylamino)phenyl]-5-isoquinolinesulfonamide. USE:An ameliorant for cerebral circulation, remedy for angina pectoris, preventive and treating agent for thrombosis, etc. PREPARATION:A compound expressed by formula II is reacted with a compound expressed by formula III, reactive derivative or salt thereof in the presence of a base and, as desired, alkylated to afford the compound expressed by formula I. The above-mentioned reaction is carried out in the presence of pyridine serving also as the base and further DMF, chloroform, etc., as a solvent and triethylamine, NaOH, etc., are also used as the base.
More Like This:
Inventors:
Hiroyoshi Hidaka
Tomohiko Ishikawa
Masatoshi Hagiwara
Inoue
Masayuki Yuasa
Takayuki Inaba
Kenji Naito
Osamu Sakuma
Tadashi Morita
Tomohiko Ishikawa
Masatoshi Hagiwara
Inoue
Masayuki Yuasa
Takayuki Inaba
Kenji Naito
Osamu Sakuma
Tadashi Morita
Application Number:
JP1171990A
Publication Date:
June 05, 2000
Filing Date:
January 23, 1990
Export Citation:
Assignee:
Hiroyoshi Hidaka
Toryo Pharmaceutical Co., Ltd.
Toryo Pharmaceutical Co., Ltd.
International Classes:
A61K31/47; A61K31/472; A61K31/495; A61K31/498; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P35/00; C07D217/02; C07D217/22; C07D401/12; C07D401/14; C07D403/12; C07D471/04; (IPC1-7): C07D217/22; C07D401/12; C07D403/12
Domestic Patent References:
| JP2256666A | ||||
| JP57156463A | ||||
| JP58121278A | ||||
| JP62103066A |
Attorney, Agent or Firm:
Hiroshi Nakamoto (1 outside)