Title:
【発明の名称】タンパク質D―インフルエンザ菌のIgD結合タンパク質
Document Type and Number:
Japanese Patent JP3066072
Kind Code:
B2
Abstract:
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
Inventors:
Forsgren, Arne
Application Number:
JP50652291A
Publication Date:
July 17, 2000
Filing Date:
February 21, 1991
Export Citation:
Assignee:
Forsgren, Arne
International Classes:
A61K39/00; A61K39/102; A61P31/04; C07K14/005; C07K14/195; C07K14/285; C07K14/41; C07K14/705; C07K16/00; C07K16/12; C07K19/00; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12N15/31; C12P21/00; C12P21/08; G01N33/53; G01N33/569; G01N33/577; A61K38/00; C12R1/19; C12R1/21; C12R1/91; (IPC1-7): C07K14/285; C07K16/12; C12N1/21; C12N5/10; C12N15/09; C12P21/08; G01N33/53; G01N33/569; G01N33/577
Attorney, Agent or Firm:
Kazuo Sato (2 outside)