Title:
【発明の名称】カリウムチャンネル開放物質としてのベンゾピラン類
Document Type and Number:
Japanese Patent JP3137649
Kind Code:
B2
Abstract:
PCT No. PCT/EP94/00637 Sec. 371 Date Aug. 4, 1995 Sec. 102(e) Date Aug. 4, 1995 PCT Filed Mar. 4, 1994 PCT Pub. No. WO94/20491 PCT Pub. Date Sep. 15, 1994The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein the dashed line represents an optional covalent bond; X is O, NH, S or a direct link; R3 is hydroxy when the dashed line does not represent a covalent bond and R3 is absent when the dashed line represents a covalent bond; R4 is (a), when X is O, a group of formula (i), (b), when X is O, NH or S, optionally substituted hydroxyphenyl, (c) an optionally substituted 4- to 7-membered heterocyclic ring, or (d), when X is NH, a group of formula (ii). The compounds are useful for the treatment of disease associated with the altered tone or motility of smooth muscle. (I) (i) (ii)
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Inventors:
Mackenzie, Alexander Roderick
Monagan, Sandra Marina
Monagan, Sandra Marina
Application Number:
JP51957894A
Publication Date:
February 26, 2001
Filing Date:
March 04, 1994
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K9/00; A61K31/41; A61K31/4418; A61K31/443; A61K31/445; A61K31/4523; A61K31/501; A61K31/506; A61P1/00; A61P9/00; A61P9/12; A61P11/00; A61P13/02; A61P15/00; A61P25/02; A61P43/00; C07D405/04; C07D405/14; C07D493/04; (IPC1-7): C07D405/04; A61K31/41; A61K31/4418; A61K31/4523; A61K31/501; A61K31/506; A61P1/00; A61P9/00; A61P11/00; A61P43/00; C07D405/14; C07D493/04
Domestic Patent References:
| JP1287083A | ||||
| JP50129568A | ||||
| JP7242650A |
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)