Title:
【発明の名称】ステロイドスルファターゼインヒビター
Document Type and Number:
Japanese Patent JP3219408
Kind Code:
B2
Abstract:
The present invention provides a pharmaceutical composition comprising a compound admixed with a pharmaceutically acceptable diluent or carrier; wherein the compound has the the formula wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl; and wherein the compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); wherein if the sulphamate group on the compound were to be replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37°C it would provide a Km value of less than 50 µM; and wherein at least one of R1 and R2 is H.
Inventors:
Reed, michael john
Potter, Barry Victor Lloyd
Potter, Barry Victor Lloyd
Application Number:
JP50503293A
Publication Date:
October 15, 2001
Filing Date:
August 28, 1992
Export Citation:
Assignee:
Sterix limited
International Classes:
A61K31/565; A61K31/00; A61K31/145; A61K31/56; A61K31/566; A61K31/567; A61K31/5685; A61P5/30; A61P5/32; A61P5/36; A61P35/00; A61P43/00; C07C307/02; C07J1/00; C07J31/00; C07J41/00; C07J43/00; C12N9/16; (IPC1-7): A61K31/565; A61P5/30; A61P35/00; C07J31/00; C12N9/16
Other References:
【文献】英国特許1398026(GB,B)
Attorney, Agent or Firm:
Shusaku Yamamoto