Title:
【発明の名称】モノアミン再取込み部位のマッピング用ヨウ素付加神経プローブ
Document Type and Number:
Japanese Patent JP3228422
Kind Code:
B2
Abstract:
An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: wherein R=a CnH2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including nF where n=18 or 19, or a mCnH2n+1 group where n=1-6 and where m=11 or 14 for at least one mC; R'=a CnH2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH3, or Sn(R''1R''2R''3); R''1=a CnH2n+1 group where n=1-6, or an aryl group; R''2=a CnH2n+1 group where n=1-6, or an aryl group; R''3=a CnH2n+1 group where n=1-6, or an aryl group; and Y=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I. Related analogs are also provided. Additionally, a precursor of a radiolabled neuroprobe and a kit for preparing the iodinated neuroprobe are provided.
Inventors:
New Mayer, John, Elle.
Milias, Richard, A.
Innis, Robert, Bee.
Milias, Richard, A.
Innis, Robert, Bee.
Application Number:
JP50343995A
Publication Date:
November 12, 2001
Filing Date:
June 29, 1993
Export Citation:
Assignee:
Research Biochemicals Limited Partnership
International Classes:
A61K51/00; C07D451/02; C07D471/08; (IPC1-7): A61K51/00
Other References:
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，Ｖｏｌ．３６，Ｎｏ．７（１９９３年４月２日）Ｐ．８５５−８６２
Attorney, Agent or Firm:
Teruo Akimoto