Title:
【発明の名称】新規ポリペプチド化合物およびそれらの製造方法
Document Type and Number:
Japanese Patent JP3307410
Kind Code:
B2
Abstract:
A polypeptide compound of the following general formula : wherein R<1> is hydrogen or acyl group, R<2> is hydroxy or acyloxy, R<3> is hydrogen or hydroxysulfonyloxy, and R<4> is hydrogen or carbamoyl, with proviso that (i) R<2> is acyloxy, when R<3> is hydrogen, and (ii) R<1> is not palmitoyl, when R<2> is hydroxy, R<3> is hydroxysulfonyloxy and R<4> is carbamoyl, and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them. The invention relates also to intermediates of the formula wherein R<6> is (C4-C6)alkoxy, higher alkoxy or higher alkenyloxy, and R<7> is -COOH or -SO3H, or its reactive derivative at the carboxy group or a salt thereof and Wherein R<8> is 1 to 4 halogen, and R<9> is lower alkoxy which has one or more halogen, higher alkoxy which has one or more halogen, or its reactive derivative at the carboxy group or a salt thereof. The invention also relates to a biologically pure culture of the microorganism Coelomycetes strain F-11899 (FERM BP-2635).
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Inventors:
Toshiro Iwamoto
Akihiko Fujie
Kumiko Nitta
Yasuhisa Tsuruumi
Shinji Shigematsu
Chiyoshi Kasahara
Motohiro Hino
Masakuni Okuhara
Kazuo Sakane
Koji Kawabata
Hidenori Ohki
Akihiko Fujie
Kumiko Nitta
Yasuhisa Tsuruumi
Shinji Shigematsu
Chiyoshi Kasahara
Motohiro Hino
Masakuni Okuhara
Kazuo Sakane
Koji Kawabata
Hidenori Ohki
Application Number:
JP24528491A
Publication Date:
July 24, 2002
Filing Date:
June 18, 1991
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
International Classes:
A61K38/12; A61P31/04; A61P31/10; C07C309/43; C07K1/06; C07K7/56; C07K7/64; A61K38/00; C12P21/04; C12R1/645; (IPC1-7): C07K7/56; A61K38/00; A61P31/04; C07C309/43; C07K1/06
Domestic Patent References:
| JP4217698A | ||||
| JP3184921A |
Attorney, Agent or Firm:
Eiji Tabuse