Title:
【発明の名称】多価の一本鎖抗体
Document Type and Number:
Japanese Patent JP3312357
Kind Code:
B2
Abstract:
The present invention discloses multivalent single chain antibodies which have two or more biologically active antigen binding sites. The multivalent single chain antibodies are formed by using a peptide linker to covalently link two or more single chain antibodies, each single chain antibody having a variable light domain linked to a variable heavy chain domain by a peptide linker.
Inventors:
Methes, Peter S.
Gory, Brian Bee.
Gory, Brian Bee.
Application Number:
JP51443794A
Publication Date:
August 05, 2002
Filing Date:
December 10, 1993
Export Citation:
Assignee:
The Dow Chemical Company
International Classes:
C12N15/09; C07K16/00; C07K16/18; C07K16/30; C07K16/32; C07K16/42; C07K16/46; C07K19/00; C12N15/13; C12P21/08; A61K38/00; C12R1/19; (IPC1-7): C07K16/46; C12N15/09; C12P21/08
Other References:
【文献】国際公開91/19739(WO,A1)
【文献】欧州特許出願公開506124(EP,A1)
【文献】欧州特許出願公開506124(EP,A1)
Attorney, Agent or Firm:
Takashi Ishida (2 outside)