Title:
【発明の名称】Neuを介して起こる形質転換の抑制方法とそのための組成物
Document Type and Number:
Japanese Patent JP3323491
Kind Code:
B2
Abstract:
PCT No. PCT/US91/09100 Sec. 371 Date Jun. 4, 1993 Sec. 102(e) Date Jun. 4, 1993 PCT Filed Dec. 4, 1991Disclosed are methods and compositions for the suppression of expression of the neu oncogene, as well as suppression of neu oncogene-mediated transformation, tumorigenesis and metastasis. The method disclosed involved introduction of adenovirus early 1A gene (the E1A gene) products into affected cells. These products, which are preferably introduced by transfection of the E1A gene into affected cells, serve to suppress neu gene expression as measured by a reduction of p185 expression. Furthermore, the E1A gene products surprisingly serve to suppress the oncogenic phenotype, as indicated by a reduction in cell growth, growth in soft agar, as well as tumorigenic and metastatic potential in vivo. The inventors propose that E1A gene products, or derivatives therefrom, may ultimately be employed a treatment modalities for neu-mediated cancers, such as cancers of the female genital tract and breast.
Inventors:
Han, Mean-Chi
You, Difa
You, Difa
Application Number:
JP2001234289A
Publication Date:
September 09, 2002
Filing Date:
August 01, 2001
Export Citation:
Assignee:
Board of Regents, The University of Texas System
International Classes:
A61K31/7088; A61K35/76; A61K38/00; A61K38/16; A61K48/00; A61P35/00; C12N15/09; C07K14/075; C07K14/71; C12N15/34; (IPC1-7): A61K38/00; A61K35/76; A61K48/00; A61P35/00; C12N15/09
Other References:
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，８７（１９９０），ｐ．４４９９−４５０３
Attorney, Agent or Firm:
Shusaku Yamamoto