Title:
【発明の名称】抗血栓剤及び抗フォンビルブランド因子モノクローナル抗体
Document Type and Number:
Japanese Patent JP3331377
Kind Code:
B2
Abstract:
A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
Inventors:
Mitsuyo Nagano
Hiroshi Yamamoto
Morikazu Kito
Ryota Yoshimoto
Miki Kobayashi
Hiroshi Yamamoto
Morikazu Kito
Ryota Yoshimoto
Miki Kobayashi
Application Number:
JP51858396A
Publication Date:
October 07, 2002
Filing Date:
November 29, 1995
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
C07K16/36; C12N5/20; C12P21/08; A61K38/00; (IPC1-7): C12P21/08; A61K39/395; A61P7/02; C07K16/36; C12N5/10
Other References:
Ｂｌｏｏｄ，Ｖｏｌ．７７，Ｎｏ．１，Ｐ．１１３−１２０（１９９１）
Ｂｌｏｏｄ，Ｖｏｌ．８０，Ｎｏ．１，Ｐ．１１３−１２０（１９９２）
Ｃｉｒｃｕｌａｔｉｏｎ，Ｖｏｌ．８６，Ｎｏ．６，Ｐ．１８５９−１８６３（１９９２）
Ｔｈｒｏｍｂ．Ｈａｅｍｏｓｔａｓｉｓ，Ｖｏｌ．５７，Ｎｏ．３，Ｐ．２７８−２８２（１９８７）
Ｔｈｒｏｍｂ．Ｈａｅｍｏｓｔａｓｉｓ，Ｖｏｌ．６０，Ｎｏ．２，Ｐ．１８２−１８７（１９８８）
Ｂｌｏｏｄ，Ｖｏｌ．８０，Ｎｏ．１，Ｐ．１１３−１２０（１９９２）
Ｃｉｒｃｕｌａｔｉｏｎ，Ｖｏｌ．８６，Ｎｏ．６，Ｐ．１８５９−１８６３（１９９２）
Ｔｈｒｏｍｂ．Ｈａｅｍｏｓｔａｓｉｓ，Ｖｏｌ．５７，Ｎｏ．３，Ｐ．２７８−２８２（１９８７）
Ｔｈｒｏｍｂ．Ｈａｅｍｏｓｔａｓｉｓ，Ｖｏｌ．６０，Ｎｏ．２，Ｐ．１８２−１８７（１９８８）
Attorney, Agent or Firm:
Tsutomu Toyama (2 outside)