Title:
【発明の名称】TGF―βとの共同的組合せによる骨修復のための骨形成タンパク質の使用
Document Type and Number:
Japanese Patent JP3356775
Kind Code:
B2
Abstract:
Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGF- beta z to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
Inventors:
Benz han
Thompson, Andrea Wai.
Armstrong, rosa
Rosen, David M.
Thompson, Andrea Wai.
Armstrong, rosa
Rosen, David M.
Application Number:
JP50267692A
Publication Date:
December 16, 2002
Filing Date:
November 27, 1991
Export Citation:
Assignee:
Sertrics Pharmaceuticals, Inc.
International Classes:
A61K38/18; A61P19/00; A61K38/00; A61P43/00; C07K14/495; C07K14/51; C07K14/52; (IPC1-7): A61K38/00; A61P19/00
Other References:
Ａｎｎ．Ｎ．Ｙ．Ａｃａｄ，Ｓｃｉ．，Ｖｏｌ．５９３（１９９０）ｐ．９８−１０６
Ｂｉｏｍａｔｅｒｉａｌｓ，Ｖｏｌ．１１（１９９０）ｐ．３３−３４
Ｃｏｎｎｅｃｔ．Ｔｉｓｓｕｅ Ｒｅｓ．，Ｖｏｌ．２０，Ｎｏ．１−４（１９８９）ｐ．３０３−３１２
Ｄｅｖ．Ｂｉｏｌ．，Ｖｏｌ．１３０，Ｎｏ．２（１９８８）ｐ．４３５−４４２
Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６４，Ｎｏ．３２（１９８９）ｐ．２０８０５−２０８１０
Ｍａｔｒｉｘ，Ｖｏｌ．１１，Ｎｏ．４（１９９１）ｐ．２６９−２７５
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，Ｖｏｌ．８７，Ｎｏ．８（１９９０）ｐ．３０２３−３０２６
Ｐｒｏｇ．Ｇｒｏｗｔｈ Ｆａｃｔｏｒ Ｒｓｅ．，Ｖｏｌ．１，Ｎｏ．４（１９８９）ｐ．２６７−２８０
Ｂｉｏｍａｔｅｒｉａｌｓ，Ｖｏｌ．１１（１９９０）ｐ．３３−３４
Ｃｏｎｎｅｃｔ．Ｔｉｓｓｕｅ Ｒｅｓ．，Ｖｏｌ．２０，Ｎｏ．１−４（１９８９）ｐ．３０３−３１２
Ｄｅｖ．Ｂｉｏｌ．，Ｖｏｌ．１３０，Ｎｏ．２（１９８８）ｐ．４３５−４４２
Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６４，Ｎｏ．３２（１９８９）ｐ．２０８０５−２０８１０
Ｍａｔｒｉｘ，Ｖｏｌ．１１，Ｎｏ．４（１９９１）ｐ．２６９−２７５
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，Ｖｏｌ．８７，Ｎｏ．８（１９９０）ｐ．３０２３−３０２６
Ｐｒｏｇ．Ｇｒｏｗｔｈ Ｆａｃｔｏｒ Ｒｓｅ．，Ｖｏｌ．１，Ｎｏ．４（１９８９）ｐ．２６７−２８０
Attorney, Agent or Firm:
Shusaku Yamamoto