Title:
【発明の名称】位相学的に分離された、コードされた固相ライブラリー
Document Type and Number:
Japanese Patent JP3394777
Kind Code:
B2
Abstract:
The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.
Inventors:
Leble, michael
Lamb, Kit S.
Salmon, Sydney E.
Kuruschnack, Victor
Sepetov, Nikolai
Cosis, peter
Lamb, Kit S.
Salmon, Sydney E.
Kuruschnack, Victor
Sepetov, Nikolai
Cosis, peter
Application Number:
JP50102295A
Publication Date:
April 07, 2003
Filing Date:
May 27, 1994
Export Citation:
Assignee:
Selectide Corporation
International Classes:
G01N33/53; C07B61/00; C07K1/04; C07K17/00; G01N33/543; G01N33/566; C40B70/00; (IPC1-7): G01N33/543; C07B61/00; C07K17/00; G01N33/53; G01N33/566
Other References:
【文献】国際公開92/91(WO,A1)
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)