Title:
特異的結合剤
Document Type and Number:
Japanese Patent JP3514456
Kind Code:
B2
Abstract:
A reshaped human antibody or reshaped human antibody fragment having specificity for human polymorphic epithelial mucin (PEM) is produced by transferring the complementarity determining regions (CDRs) from a murine anti-HMFG hybridoma cell line HMFG1 into a human antibody variable region framework. The reshaped molecule can be used in the treatment or diagnosis of cancer.
Inventors:
バーホーエン、マーチン・エリサ
Application Number:
JP51496191A
Publication Date:
March 31, 2004
Filing Date:
September 05, 1991
Export Citation:
Assignee:
インペリアル キャンサー リサーチ テクノロジー リミテッド
International Classes:
A61K39/395; A61K49/00; A61P35/00; C07K7/06; C07K7/08; C07K14/00; C07K16/00; C07K16/18; C07K16/30; C07K16/46; C12N1/21; C12N15/09; C12N15/13; C12P21/02; C12P21/08; G01N33/53; G01N33/574; A61K38/00; C12R1/19; (IPC1-7): C12P21/08; A61K39/395; A61K49/00; C07K16/18; C12N15/09
Other References:
Ｎａｔｕｒｅ，ｖｏｌ ３３２，ｎｏ．６１６２（１９８８）ｐ．３２３−３２７
Attorney, Agent or Firm:
山崎 行造