Title:
バシラスリケニフォーミス菌株から由来したアミノペプチダーゼ及び天然蛋白質の製造方法
Document Type and Number:
Japanese Patent JP3518868
Kind Code:
B2
Abstract:
The present invention relates to a process for removing methionine (Met) residue at N-terminus of proteins specifically. Particularly, the present invention relates to an aminopeptidase which is purified from Bacillus licheniformis removes a methionine residue from N-terminus of peptide and proteins. And the present invention relates to a process for preparing a natural type protein from proteins produced in microorganisms by recombinant DNA technology. Various kinds of natural type proteins such as human growth hormone (HGH) can be prepared massively and easily by the process of the present invention.
Inventors:
キム，セ−フーン
パーク，スーン−ジェ
ハン，キュボエム
リー，セウン−ジュー
リー，ヨウン−フィル
パーク，スーン−ジェ
ハン，キュボエム
リー，セウン−ジュー
リー，ヨウン−フィル
Application Number:
JP53753098A
Publication Date:
April 12, 2004
Filing Date:
February 16, 1998
Export Citation:
Assignee:
エルジー ケミカル リミテッド
International Classes:
C07K14/61; C12N15/09; C12N9/48; C12N15/18; C12N15/57; C12P21/02; (IPC1-7): C12N9/48; C12P21/02
Other References:
Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ，１９７８，１８６（２），ｐ．３８３−３９１
Attorney, Agent or Firm:
松本 武彦