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Title:
多発性硬化症を含めた炎症の治療におけるペプチドＴ及びその関連ペプチド類
Document Type and Number:
Japanese Patent JP3520084
Kind Code:
B2
Abstract:
Peptide T and its linear or cyclic analogues of the General Formula 1: I-A-B-C-D-E-F-G-H-II wherein A is Ala, Gly, Val, Ser, Thr or absent; B is Ala, Gly, Val, Ser, Thr or absent; C is Ser, Thr or absent; D is Ser, Thr, Asn, Glu, Arg, Ile, Leu or absent; E is Ser, Thr, Asp or absent; F is Thr, Ser, Asn, Arg, Gln, Lys, Trp or absent; G is Tyr or absent; H is Thr, Arg, Gly, Met, Met(O), Cys, Thr, Gly or absent; and I is Cys or absent; II is Cys, an amide group, substituted amide group, an ester group or absent; at least one of the amino acids optionally being substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino and/or amido groups of the amino acids, comprising at least 4 amino acids, and their pharmaceutically acceptable salts, are useful in the treatment or prevention of inflammation. In particular, the peptides are useful in the treatment or prevention of multiple sclerosis, myelopathies (including HTLV-1 associate myelopathy) and symptoms and diseases associated with chronic immune activation, including chronic fatigue syndrome, toxic shock, arthritis, inflammatory bowel disease and host-versus-graft and graft-versus-host responses in transplant recipients.

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Inventors:
アストン，ロジャー
アンデルセン，アンダース ジョルゲン
ウィドマー，フレッド
カーレン，ペーター ルイス
ドゥーブ，ペネロープ リード
フィップス，デビッド ジェームス
マクファーデン，ダグラス ケビン
ラスジェン，デボラー
Application Number:
JP51722093A
Publication Date:
April 19, 2004
Filing Date:
March 29, 1993
Export Citation:
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Assignee:
アドバンスト イムニ ティ，インコーポレーテッド
International Classes:
A61K38/08; A61K38/18; A61K47/48; A61P29/00; A61K38/00; C07K5/10; C07K5/103; C07K7/06; C07K14/00; C07K14/155; C07K14/16; (IPC1-7): A61K38/00; A61P29/00
Other References:
Ａｃｔａ Ｄｅｒｍ Ｖｅｎｅｒｅｏｌ，Ｖｏｌ．６９（１），ｐ．８６−８８（１９８９）
Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ，Ｖｏｌ．１７１（２），ｐ．５９６−６０２（１９９０）
Ｉｎｔ．Ｊ．Ｐｅｐｔｉｄｅ Ｐｒｏｔｅｉｎ Ｒｅｓ．，Ｖｏｌ．３５，ｐ．８１−８８（１９９０）
Attorney, Agent or Firm:
三宅 正夫



 
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